Role Of Corticosteroids In Covid

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Salient features:

This article focuses on :

    • Cytokine release syndrome(CRS)

Detailed summary :

Cytokine release syndrome(CRS)

    • Causes¬† ARDS,myocarditis,myocardial injury and multiorgan dysfunction syndrome (MODS)
    • Onset : tocilizumab(anti IL-6)
    • Corticosteroids are used to stop cytokine release.¬†
    • Lymphocytes release cytokines. So the lymphocyte trend is tracked by doing CBC twice a day.
    • Methylprednisolone 1 mg/kg ODx3 to 5days is administered at a point when lymphocytopenia turns into lymphocytosis to preempt the cytokine storm,MODS and crashing.
    • Steroids used in septic shock, acute exacerbation of asthma and COPD.
    • CBC should be done 6hrly to pick up the lymphocytosis early.
    • Monitoring IL-6 is ideal and then using its antagonist tocilizumab

 

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