Salient features :
This article focuses on :
- Hydroxychloroquine & hypoxic pneumonia
- Timing of viral shedding & transmissibility
- Coinfection with other respiratory pathogens
- Decontaminating N95 masks
- Predicting the pandemic’s course
Detailed summary :
Hydroxychloroquine & hypoxic pneumonia:
- Administration of hydoxychloroquine (600 mg daily) to the patients with COVID-19 symptoms requiring oxygen did not show significant difference in the reduction of symptoms compared to patients who didnt receive the drug.
Timing of viral shedding & transmissibility:
- The infectiousness began 2.3 days before symptom onset and peaked 0.7 days before symptoms began.
- Presymptomatic transmission was accounted for 44% of secondary cases among the transmission pairs.
Coinfection with other respiratory pathogens:
- Nasopharyngeal swab specimens of patients tested positive for SARS-CoV-2 were sometimes tested positive for other respiratory pathogens like rhinovirus/enterovirus and respiratory syncytial virus.
- This indicated that the presence of a non–SARS-CoV-2 pathogen may not provide reassurance that a patient does not also have SARS-CoV-2.
Decontaminating N95 masks:
- 70% ethanol: Virus was not detected on masks but degraded mask integrity after 30 minutes of decontamination.
- Ultraviolet light : virus was detected on mask and degraded mask integrity.
- Vaporized hydrogen peroxide : virus was detected on mask but didnt change the mask integrity.
Predicting the pandemic’s course:
- Model used : Institute for Health Metrics and Evaluation’s model
- Flaws : unreliable mortality data.
- Feedback : patient-level clinical outcome data should be used