COVID-19: Hydroxychloroquine & Hypoxic Pneumonia / Timing of Viral Shedding & Transmission / Coinfection with Other Respiratory Pathogens

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Salient features :

This article focuses on :

  • Hydroxychloroquine & hypoxic pneumonia
  • Timing of viral shedding & transmissibility
  • Coinfection with other respiratory pathogens
  • Decontaminating N95 masks
  • Predicting the pandemic’s course

Detailed summary :

Hydroxychloroquine & hypoxic pneumonia: 

  • Administration of hydoxychloroquine (600 mg daily) to the patients with COVID-19 symptoms requiring oxygen did not show significant difference in the reduction of symptoms compared to patients who didnt receive the drug.

Timing of viral shedding & transmissibility:

  •  The infectiousness began 2.3 days before symptom onset and peaked 0.7 days before symptoms began. 
  • Presymptomatic transmission was accounted for 44% of secondary cases among the transmission pairs.

Coinfection with other respiratory pathogens:

  • Nasopharyngeal swab specimens of patients tested positive for SARS-CoV-2 were sometimes tested positive for other respiratory pathogens like rhinovirus/enterovirus and respiratory syncytial virus.
  • This indicated that the presence of a non–SARS-CoV-2 pathogen may not provide reassurance that a patient does not also have SARS-CoV-2.

Decontaminating N95 masks:

Methods :

  • 70% ethanol: Virus was not detected on masks but degraded mask integrity after 30 minutes of decontamination.
  • Ultraviolet light :  virus was detected on mask and degraded mask integrity.
  • Vaporized hydrogen peroxide : virus was detected on mask but didnt change the mask integrity.

Predicting the pandemic’s course:

  • Model used : Institute for Health Metrics and Evaluation’s model 
  • Flaws : unreliable mortality data.
  • Feedback : patient-level clinical outcome data should be used 

Reference Link : https://www.jwatch.org/fw116555/2020/04/15/covid-19-hydroxychloroquine-hypoxic-pneumonia-timing

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